Utilizing a regulated targeted integration cell line development approach to systematically investigate what makes an antibody difficult to express
Author:
Affiliation:
1. Chugai Pharmaceutical Co., Ltd.API Process Development Dept. (Biotechnology) Tokyo 115‐8543 Japan
2. Dept. of Cell CultureGenentech Inc. South San Francisco California 94080
Publisher
Wiley
Subject
Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/btpr.2772
Reference31 articles.
1. Expression systems for therapeutic glycoprotein production
2. Therapeutic antibodies for autoimmunity and inflammation
3. Post-translational modifications in the context of therapeutic proteins
4. CHO cells in biotechnology for production of recombinant proteins: current state and further potential
5. Fast identification of reliable hosts for targeted cell line development from a limited-genome screening using combined φC31 integrase and CRE-Lox technologies
Cited by 12 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Promoting the production of challenging proteins via induced expression in CHO cells and modified cell-free lysates harboring T7 RNA polymerase and mutant eIF2α;Synthetic and Systems Biotechnology;2024-09
2. Evaluation of two transposases for improving expression of recombinant proteins in Chinese hamster ovary cell stable pools by co‐transfection and supertransfection approaches;Biotechnology Progress;2024-07-17
3. SPEED‐MODE cell line development (CLD): Reducing Chinese hamster ovary (CHO) CLD timelines via earlier suspension adaptation and maximizing time spent in the exponential growth phase;Biotechnology Progress;2024-05-08
4. A systemic approach to identifying sequence frameworks that decrease mAb production in a transient Chinese hamster ovary cell expression system;Biotechnology Progress;2024-04-12
5. Repressing expression of difficult‐to‐express recombinant proteins during the selection process increases productivity of CHO stable pools;Biotechnology and Bioengineering;2023-05-26
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3