Host transcriptomic signatures of tuberculosis can predict immune reconstitution inflammatory syndrome in HIV patients

Author:

Mbandi Stanley Kimbung1,Painter Hannah2,Penn‐Nicholson Adam1,Toefy Asma1,Erasmus Mzwandile1,Hanekom Willem A.1,Scriba Thomas J.1,Lai Rachel P.J.3,Marais Suzaan45,Fletcher Helen A.2,Meintjes Graeme45,Wilkinson Robert J.3456,Cotton Mark F.7,Pahwa Savita8,Cameron Mark J.9,Nemes Elisa1ORCID

Affiliation:

1. South African Tuberculosis Vaccine Initiative (SATVI) Institute of Infectious Disease and Molecular Medicine and Division of Immunology Department of Pathology University of Cape Town Cape Town South Africa

2. Department of Infection Biology London School of Hygiene & Tropical Medicine London UK

3. Department of Infectious Diseases Imperial College London London UK

4. Wellcome Centre for Infectious Diseases Research in Africa University of Cape Town Observatory South Africa

5. Institute of Infectious Disease and Molecular Medicine and Department of Medicine University of Cape Town Observatory South Africa

6. Francis Crick Institute London UK

7. Family Center for Research with Ubuntu Department of Pediatrics & Child Health Faculty of Medicine and Health Sciences Stellenbosch University Tygerberg South Africa

8. Department of Microbiology and Immunology Miami Center for AIDS Research University of Miami Miller School of Medicine Miami Florida USA

9. Department of Population & Quantitative Health Sciences Case Western Reserve University School of Medicine Cleveland Ohio USA

Funder

United States Agency for International Development

Cancer Research UK

UK Research and Innovation

Wellcome Trust

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

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