Affiliation:
1. Department of Dermatology, Venereology and Allergology Charité‐Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
2. BIH Charité Clinician Scientist Program, Berlin Institute of Health at Charité–Universitätsmedizin Berlin BIH Biomedical Innovation Academy Berlin Germany
Abstract
AbstractStudies on the role of interleukins (ILs) in autoimmune and inflammatory diseases allow for the better understanding of pathologic mechanisms of disease and reshaping of treatment modalities. The development of monoclonal antibodies targeting specific ILs or IL signaling pathways (i.e., anti‐IL‐17/IL‐23 in psoriasis or anti‐IL‐4/IL‐13 in atopic dermatitis) is the shining example of therapeutic interventions in research. IL‐21, belonging to the group of ɣc‐cytokines (IL‐2, IL‐4, IL‐7, IL‐9, and IL‐15), is gaining attention for its pleiotropic role in several types of immune cells as activator of various inflammatory pathways. In both health and disease, IL‐21 sustains T‐ and B‐cell activity. Together with IL‐6, IL‐21 helps to generate Th17 cells, promotes CXCR5 expression in T cells, and their maturation into follicular T helper cells. In B cells, IL‐21 sustains their proliferation and maturation into plasma cells and promotes class switching and antigen‐specific antibody production. Due to these characteristics, IL‐21 is a main factor in numerous immunologic disorders, such as rheumatoid arthritis and MS. Studies in preclinical skin disease models and on human skin strongly suggest that IL‐21 is crucially involved in inflammatory and autoimmune cutaneous disorders. Here, we summarize the current knowledge of IL‐21 in well‐known skin diseases.
Subject
Immunology,Immunology and Allergy
Cited by
8 articles.
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