Phenotypic characteristics, healthcare use, and treatment in children with night cough compared with children with wheeze

Author:

Mallet Maria C.12ORCID,Mozun Rebeca13ORCID,Ardura‐Garcia Cristina1ORCID,Pedersen Eva S. L.1ORCID,Jurca Maja14ORCID,Latzin Philipp5ORCID,Moeller Alexander6ORCID,Kuehni Claudia E.15ORCID,

Affiliation:

1. Institute of Social and Preventive Medicine University of Bern Bern Switzerland

2. Graduate School for Health Sciences University of Bern Bern Switzerland

3. Department of Intensive Care and Neonatology, Children's Research Center, University Children's Hospital Zurich University of Zurich Zurich Switzerland

4. The University Children's Hospital Basel Basel Switzerland

5. Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital University of Bern Bern Switzerland

6. Department of Respiratory Medicine, University Children's Hospital Zurich and Children's Research Center University of Zurich Zurich Switzerland

Abstract

AbstractObjectivesPopulation‐based studies of children with dry night cough alone compared with those who also wheeze are few and inconclusive. We compared how children with dry night cough differ from those who wheeze.MethodsLuftiBus in the school is a population‐based study of schoolchildren conducted between 2013 and 2016 in Zurich, Switzerland. We divided children into four mutually exclusive groups based on reported dry night cough (henceforth referred as “cough”) and wheeze and compared parent‐reported symptoms, comorbidities, exposures, FeNO, spirometry, and healthcare use and treatment.ResultsAmong 3457 schoolchildren aged 6–17 years, 294 (9%) reported “cough,” 181 (5%) reported “wheeze,” 100 (3%) reported “wheeze and cough,” and 2882 (83%) were “asymptomatic.” Adjusting for confounders in a multinomial regression, children with “cough” reported more frequent colds, rhinitis, and snoring than “asymptomatic” children; children with “wheeze” or “wheeze and cough” more often reported hay fever, eczema, and parental histories of asthma. FeNO and spirometry were similar among “asymptomatic” and children with “cough,” while children with “wheeze” or “wheeze and cough” had higher FeNO and evidence of bronchial obstruction. Children with “cough” used healthcare less often than those with “wheeze,” and they attended mainly primary care. Twenty‐two children (7% of those with “cough”) reported a physician diagnosis of asthma and used inhalers. These had similar characteristics as children with wheeze.ConclusionOur representative population‐based study confirms that children with dry night cough without wheeze clearly differed from those with wheeze. This suggests asthma is unlikely, and they should be investigated for alternative aetiologies, particularly upper airway disease.

Publisher

Wiley

Subject

Pulmonary and Respiratory Medicine,Pediatrics, Perinatology and Child Health

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