Nuclear hydroxylated metabolite of fluradoline (2-fluoro-11-[(β-methylamino)ethylthio]dibenz[b,f]oxepin hydrochloride). Identification and synthesis-Reference-Cited by-同舟云学术

Nuclear hydroxylated metabolite of fluradoline (2-fluoro-11-[(β-methylamino)ethylthio]dibenz[b,f]oxepin hydrochloride). Identification and synthesis

Published:1986-01 Issue:1 Volume:23 Page:265-269
ISSN:0022-152X
Container-title:Journal of Heterocyclic Chemistry
language:en
Short-container-title:

Author:

Agnew Marc N.,Rizwaniuk Anastasia,Ong Helen H.,Wichmann J. K.

Publisher

Wiley

Subject

Organic Chemistry

Reference6 articles.

1. Tricyclics with analgesic and antidepressant activity. 1. [[(Alkylamino)ethyl]thio]dibenz[b,f]oxepins and 10,11-dihydro derivatives

2. Analogs of hycanthone and lucanthone as antitumor agents

3. In a somewhat analogous manner, attempts to cyclize 4-(2-carboxy-4-methoxybenzyloxy)phenylacetic acid by the intramolecular Friedel Crafts reaction (SOCl2, AlCl3) resulted in the formation of 3-methoxy-phthalide, possibly through a similar quinoid intermediate; private communications, R. C. Allen and G. M. Shutske.

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