Genome-wide gene-environment interaction in depression: A systematic evaluation of candidate genes

Author:

Van der Auwera Sandra1ORCID,Peyrot Wouter J.2,Milaneschi Yuri2,Hertel Johannes1,Baune Bernhard3,Breen Gerome45,Byrne Enda6,Dunn Erin C.789,Fisher Helen4,Homuth Georg10,Levinson Douglas11,Lewis Cathryn412,Mills Natalie3,Mullins Niamh4,Nauck Matthias1314,Pistis Giorgio15,Preisig Martin15,Rietschel Marcella16,Ripke Stephan171819,Sullivan Patrick202122,Teumer Alexander23,Völzke Henry23,Boomsma Dorret I.24,Wray Naomi R.625,Penninx Brenda2,Grabe Hans1,

Affiliation:

1. Department of Psychiatry and Psychotherapy; University Medicine Greifswald; Greifswald Germany

2. Department of Psychiatry; Vrije Universiteit Medical Center and GGZ in Geest; Amsterdam The Netherlands

3. Discipline of Psychiatry; University of Adelaide; Adelaide Australia

4. Institute of Psychiatry; Psychology and Neuroscience; MRC Social Genetic and Developmental Psychiatry Centre; King's College London; London Great Britain

5. NIHR BRC for Mental Health; King's College London; London Great Britain

6. Queensland Brain Institute; The University of Queensland; Brisbane Australia

7. Stanley Center for Psychiatric Research; Broad Institute; Cambridge Massachusetts

8. Department of Psychiatry; Massachusetts General Hospital; Boston Massachusetts

9. Psychiatric and Neurodevelopmental Genetics Unit (PNGU); Massachusetts General Hospital; Boston Massachusetts

10. Interfaculty Institute for Genetics and Functional Genomics; Department of Functional Genomics; University Medicine and Ernst Moritz Arndt University Greifswald; Greifswald Germany

11. Psychiatry and Behavioral Sciences; Stanford University; Stanford California

12. Department of Medical and& Molecular Genetics; King's College London; London Great Britain

13. DZHK (German Centre for Cardiovascular Research); Partner Site Greifswald; University Medicine Greifswald; Greifswald Germany

14. Institute of Clinical Chemistry and Laboratory Medicine; University Medicine Greifswald; Greifswald Germany

15. Department of Psychiatry; University Hospital of Lausanne; Prilly Switzerland

16. Department of Genetic Epidemiology in Psychiatry; Central Institute of Mental Health; Mannheim Germany

17. Medical and Population Genetics; Broad Institute; Cambridge Massachusetts

18. Analytic and Translational Genetics Unit; Massachusetts General Hospital; Boston Massachusetts

19. Department of Psychiatry and Psychotherapy; University medicine Berlin Campus Charité Mitte; Berlin Germany

20. Medical Epidemiology and Biostatistics; Karolinska Institute; Stockholm Sweden

21. Department of Genetics; University of North Carolina at Chapel Hill; Chapel Hill North Carolina

22. Department of Psychiatry; University of North Carolina at Chapel Hill; Chapel Hill North Carolina

23. Institute for Community Medicine; University Medicine Greifswald; Greifswald Germany

24. Department of Biological Psychology & EMGO+ Institute for Health and Care Research; Vrije Universiteit Amsterdam; Amsterdam The Netherlands

25. Institute for Molecular Bioscience; The University of Queensland; Brisbane Australia

Funder

GlaxoSmithKline Australia

European Science Council

ZonMw

National Health and Medical Research Council

NBIC/BioAssist/RK

MQ Fellows Award

BBMRI-NL

Marie Curie Industry-Academia Partnership and Pathways

Center for Medical Systems Biology

Deutsche Forschungsgemeinschaft

Netherlands Organization for Scientific Research

Bundesministerium für Bildung und Forschung

Netherlands Scientific Organization

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Rutgers University Cell and DNA Repository

National Institutes of Health

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Psychiatry and Mental health,Genetics(clinical)

Reference57 articles.

1. A map of human genome variation from population-scale sequencing;Abecasis;Nature,2010

2. Genetic variation of the FAT gene at 4q35 is associated with bipolar affective disorder;Abou Jamra;Molecular Psychiatry,2008

3. Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population;Appel;Neuropsychopharmacology,2011

4. FAT and bipolar affective disorder;Aston;Molecular Psychiatry,2007

5. Clinical, functional, and biological correlates of cognitive dimensions in major depressive disorder − rationale, design, and characteristics of the cognitive function and mood study (CoFaM-Study);Baune;Front Psychiatry,2016

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