Affiliation:
1. Laboratory of Bioinorganic Chemistry Molecular Materials and the Environment Faculty of Sciences Moulay Ismail University Meknes Kingdom of Morocco
2. Biology Environment and Health Team Faculty of Sciences and Technologies Moulay Ismail University Erachidia Morocco
3. Team of Microbiology and Health Laboratory of Chemistry‐Biology Applied to the Environment Moulay Ismail University Faculty of Sciences Zitoune Meknes Morocco
4. Laboratory of Microbial Biotechnology and Bioactive Molecules Sciences and Technologies Faculty Sidi Mohamed Ben Abdellah University Fez Morocco
5. Department of Biomedical Dental Morphological and Functional Imaging Sciences University of Messina Messina Italy
Abstract
AbstractFour new complexes of transition metals CuL2, Ni2L2(μ‐Cl)2,Cu2(LH) 2P(Ph)3(H2O)(μ‐Cl)2, [Ni(LH)P(Ph)3Cl2(H2O)]H2O, based on the ligand [2‐(benzo[d]thiazol‐2‐yl)phenol] (L) were synthesized and characterized by FTIR, NMR (1H,13C,31P), ESI‐MS and UV–visible spectroscopy. Spectral data show that the CuL2 complex has a distorted square geometry, octahedral for the Cu2(LH)2P(Ph)3(H2O)(μ‐Cl)2 [Ni(LH)P(Ph)3Cl2(H2O)]H2O complexes and tetrahedral for the Ni2L2(μ‐Cl)2 complex. Remarkable antioxidant and antibacterial activity against four strains for the complexes and ligand L was investigated. Cytotoxicity study was made on the germination of Lepidium sativum seeds, and on the behavior of erythrocytes and leukocyte nuclei. All synthesized products showed no hemolytic and genotoxic effects on erythrocytes and leukocyte nuclei, respectively. The results of the present study indicate that the synthesized ligand and its complexes tested are safe to human blood cells, and they might be used as active agents for pre‐clinical trials.
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1 articles.
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