Potential oxidoreductases inhibitors from medicinal plants‐based phytochemicals: A review

Author:

Gomes Tarsila1,Alejandro Gracebio2,Thao Tran Thi Phuong34ORCID,Vieira Amandio Vincent1

Affiliation:

1. Biomedical physiology and kinesiology (BPK) Simon Fraser University Burnaby British Columbia Canada

2. Research Centre for the Natural and Applied Sciences, Thomas Aquinas Research Complex University of Santo Tomas Manila Philippines

3. Institute of Chemistry Vietnam Academy of Science and Technology (VAST) Hanoi Vietnam

4. Faculty of Chemistry Graduate University of Science and Technology Vietnam Academy of Science and Technology (VAST) Hanoi Vietnam

Abstract

AbstractOxidoreductases (ORases) are enzymes that catalyze oxidation and reduction reactions in cells or extracellular compartments of the body. Genetic mutations and other factors that affect ORase activity have been implicated in a range of diseases, especially inherited metabolic disorders. Aldose reductase, sorbitol dehydrogenase, xanthine oxidoreductase are the ORases with relevance to diabetes pathology. Herein, the strategies for screening modulators of ORase activities, and medicinal plants whose phytochemicals have the potential to influence ORase activity, are described. The overall goal is to test and identify natural products and other compounds that may have a therapeutic benefit in relation to hyperglycemia and diabetes.

Publisher

Wiley

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