The genus Aglaia: Diversity in chemical structure and biological activity

Author:

Bang Ngo Anh12,Tai Bui Huu12,Yen Pham Hai1,Kiem Phan Van12

Affiliation:

1. Graduate University of Science and Technology Vietnam Academy of Science and Technology (VAST) Cau Giay Hanoi Vietnam

2. Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST) Hanoi Vietnam

Abstract

AbstractThe Meliaceae family has been investigated comprehensively because of their structurally multifarious, and biologically active components. The genus Aglaia has the highest amount in this family, including around 150 species. These species are widespread throughout tropical regions, particularly in Southeast Asia and Australia. They have been used in traditional medicine for treating various diseases. This article summarizes 370 metabolites, which have been isolated from several parts such as the bark, roots, seeds, and leaves of Aglaia species in over fifty years from the first investigation in 1965 to 2024, originating from the flavagline, triterpenoid, sesquiterpenoid, steroid, alkaloid, and limonoid, while flavagline is the largest group. The components isolated from the genus Aglaia are analyzed for potential biological activities, like cytotoxicity, anti‐inflammatory, insecticidal, antiviral, antituberculosis, and antifungal effects. In addition, the flavagline was reported to show a high potential for cytotoxic and insecticidal activities and was confirmed to be used as the chemical marker for this species. Therefore, these reports indicate that Aglaia species may hold potential as a valuable source for producing biologically active compounds.

Publisher

Wiley

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