Study on the interaction of K[PtCl3(L)] (L: safrole, methyleugenol, isopropyl eugenoxyacetate and piperidine)] with some heterocyclic bidentate amines

Abstract

AbstractThe interactions between K[PtCl3(L)] (L: safrole/1a, methyleugenol/1b, isopropyl eugenoxyacetate/1c, piperidine/1d) and heterocyclic bidentate amines (1,10‐phenalthroline/Phen, 2,2’‐bipyridine/Bpy, 4,4’‐dimethyl‐2,2’‐bipyridine/MeBpy, and 8‐aminoquinoline/NH2Q) were investigated for the first time. The results show that the amines readily replace the L ligand, the arylolefin or piperidine, to form complexes of the formula cis‐[PtCl2(amine)] (amine: Phen/2, Bpy/3, MeBpy/4 and NH2Q/5) in very high yields (90‐95 %). The structures of 2‐5 were analyzed by Pt percentage, IR spectroscopy, and also by ESI‐MS, 1H NMR spectroscopy for 5. The result of testing in vitro cytotoxicity of complex 5 against Hep G2, RD, MCF‐7 and Fl human cancer cell lines indicates that complex 5 exhibits greater activity against RD cell line in comparison to cisplatin with IC50 value of 6.96 μg/ml.