Can In Vitro–In Vivo Extrapolation Be Successful? Recognizing the Incorrect Clearance Assumptions-Reference-Cited by-同舟云学术

Can In Vitro–In Vivo Extrapolation Be Successful? Recognizing the Incorrect Clearance Assumptions

Published:2021-12-08 Issue: Volume: Page:
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin Pharmacol Ther

Author:

Benet Leslie Z.¹,Sodhi Jasleen K.¹

Affiliation:

1. Department of Bioengineering and Therapeutic Sciences Schools of Pharmacy and Medicine University of California San Francisco California USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2482

Reference25 articles.

1. Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization

2. Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System

3. Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology

4. There is only one valid definition of clearance: critical examination of clearance concepts reveals the potential for errors in clinical drug dosing decisions;Benet L.Z.;AAPS J.,2021

5. Prediction of human clearance of twenty‐nine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half‐life approach and nonspecific binding to microsomes;Obach R.S.;Drug Metab. Dispos.,1999

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