Affiliation:
1. Department of Anesthesiology Third Hospital of Shanxi Medical University Shanxi Bethune Hospital Shanxi Academy of Medical Sciences Tongji Shanxi Hospital Taiyuan 030032 China
2. Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University Taiyuan 030013 China
3. Laboratory of Molecular Imaging Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital) Taiyuan 030000 China
Abstract
AbstractThe development of nanoassemblies, activated by the tumor microenvironment, capable of generating photothermal therapy (PTT) and amplifying the “ROS (·OH) storm,” is essential for precise and effective synergistic tumor treatment. Herein, an innovative cascade‐amplified nanotheranostics based on biodegradable Pd‐BSA‐GOx nanocomposite for NIR‐II photoacoustic imaging (PAI) guides self‐enhanced NIR‐II PTT/chemodynamic therapy (CDT)/starvation synergistic therapy. The Pd‐BSA‐GOx demonstrates the ability to selectively convert overexpressed H2O2 into strongly toxic ·OH by a Pd/Pd2+‐mediated Fenton‐like reaction at a lower pH level. Simultaneously, the GOx generates H2O2 and gluconic acid, effectively disrupting nutrient supply and instigating tumor starvation therapy. More importantly, the heightened levels of H2O2 and increased acidity greatly enhance the Fenton‐like reactivity, generating a significant “·OH storm,” thereby achieving Pd2+‐mediated cascade‐amplifying CDT. The specific PTT facilitated by undegraded Pd accelerates the Fenton‐like reaction, establishing a positive feedback process for self‐enhancing synergetic PTT/CDT/starvation therapy via the NIR‐II guided‐PAI. Therefore, the multifunctional nanotheranostics presents a simple and versatile strategy for the precision diagnosis and treatment of tumors.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Shanxi Province Science Foundation for Youths
Key Laboratory of Highway Construction and Maintenance Technology in the Loess Region of Shanxi Transportation Research Institute