Photocurable 3D‐Printed PMBG/TCP Scaffold Coordinated with PTH (1‐34) Bidirectionally Regulates Bone Homeostasis to Accelerate Bone Regeneration

Abstract

AbstractBone defect repair remains a major clinical challenge that requires the construction of scaffolds that can regulate bone homeostasis. In this study, a photo‐cured mesoporous bioactive glass (PMBG) precursor is developed as a tricalcium phosphate (TCP) agglomerant to obtain a double‐phase PMBG/TCP scaffold via 3D printing. The scaffold exhibits multi‐scale porous structures and large surface areas, making it a suitable carrier for the loading of parathyroid hormone (PTH) (1‐34), which is used for the treatment of osteoporosis. In vitro and in vivo results demonstrate that PMBG/TCP scaffolds coordinated with PTH (1‐34) can regulate bone homeostasis in a bidirectional manner to facilitate bone formation and inhibit bone resorption. Furthermore, bidirectional regulation of bone homeostasis by PTH (1‐34) is achieved by inhibiting fibrogenic activation protein (FAP). Thus, PMBG/TCP scaffolds coordinated with PTH (1‐34) are viable materials with considerable potential for application in the field of bone regeneration and provide an excellent solution for the design and development of clinical materials.