Affiliation:
1. Department of Pharmacology School of Basic Medical Sciences Anhui Medical University Hefei 230032 China
2. Department of Microbiology School of Basic Medical Sciences Anhui Medical University Hefei 230032 China
3. Experimental Teaching Center for Preventive Medicine School of Public Health Anhui Medical University Hefei 230032 China
Abstract
AbstractRheumatoid arthritis (RA) is a chronic immune disease characterized by the infiltration of immune cells and the proliferation of fibroblast‐like synoviocytes (FLS) at the joint site, leading to inflammation and joint destruction. However, the available treatment options targeting both inflammatory and proliferative FLS are limited. Herein, this work presents three covalent organic frameworks (COFs) photothermal composite systems modified with multi‐armed polyethylene glycols (PEG) for the treatment of RA. These systems exhibit a dual response under low pH and high reactive oxygen species (ROS) conditions at the site of inflammation, with a specific focus on delivering the protein drug ribonuclease A (RNase A). Notably, molecular docking studies reveal the interaction between RNase A and NF‐κB p65 protein, and Western blotting confirm its inhibitory effect on NF‐κB activity. In vitro and in vivo experiments verify the significant reduction in joint swelling and deformities in adjuvant‐induced arthritis (AIA) rats after treatment with RNase A delivered by multi‐armed PEG‐modified COF ligands, restoring joint morphology to normal. These findings underscore the promising therapeutic potential of COFs for the treatment of RA, highlighting their unique capabilities in addressing both inflammatory and proliferative aspects of the disease and expanding the scope of biomedical applications for COFs.
Funder
Natural Science Foundation of Shandong Province
Cited by
1 articles.
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