Affiliation:
1. School of Medical Technology Beijing Institute of Technology Beijing 100081 P. R. China
Abstract
AbstractCoronavirus disease 2019 (COVID‐19) continues to threaten human health, economic development, and national security. Although many vaccines and drugs have been explored to fight against the major pandemic, their efficacy and safety still need to be improved. Cell‐based biomaterials, especially living cells, extracellular vesicles, and cell membranes, offer great potential in preventing and treating COVID‐19 owing to their versatility and unique biological functions. In this review, the characteristics and functions of cell‐based biomaterials and their biological applications in COVID‐19 prevention and therapy are described. First the pathological features of COVID‐19 are summarized, providing enlightenment on how to fight against COVID‐19. Next, the classification, organization structure, characteristics, and functions of cell‐based biomaterials are focused on. Finally, the progress of cell‐based biomaterials in overcoming COVID‐19 in different aspects, including the prevention of viral infection, inhibition of viral proliferation, anti‐inflammation, tissue repair, and alleviation of lymphopenia are comprehensively described. At the end of this review, a look forward to the challenges of this aspect is presented.
Funder
National Natural Science Foundation of China
National Science Fund for Distinguished Young Scholars
Beijing Institute of Technology Research Fund Program for Young Scholars
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials