Affiliation:
1. Institute of Biomedical Engineering College of Life Science Qingdao University Qingdao 266071 P. R. China
2. College of Materials Science and Engineering Qingdao University Qingdao 266071 P. R. China
Abstract
AbstractHeterostructure nanozymes as antibiotic‐free antimicrobial agents exhibit great potential for multidrug‐resistant (MDR) bacterial strains elimination. However, realization of heterostructure antimicrobials with enhanced interfacial interaction for synergistically amplified antibacterial therapy is still a great challenge. Herein, oxygen‐vacancy‐enriched glucose modified MoOx (G‐MoOx) is exploited as a reducing agent to spontaneously reduce Ag (I) into Ag (0) that in situ grows onto the surface of G‐MoOx. The resultant Ag doped G‐MoOx (Ag/G‐MoOx) heterostructure displays augmenting photothermal effect and NIR‐enhanced oxidase‐like activity after introducing Ag nanoparticles. What's more, NIR hyperthermia accelerate Ag+ ions release from Ag nanoparticles. Introduction of Ag greatly enhances antimicrobial activities of Ag/G‐MoOx against MDR bacteria, especially the hybrid loading with 1 wt% Ag NPs exhibiting antibacterial efficacy up to 99.99% against Methicillin‐resistant Staphylococcus aureus (MRSA, 1×106 CFU mL−1).
Funder
National Natural Science Foundation of China
Taishan Scholar Foundation of Shandong Province
Cited by
1 articles.
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