Affiliation:
1. School of Chemistry Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education Guangdong Key Laboratory of Chiral Molecule and Drug Discovery Sun Yat-Sen University 510006 Guangzhou P. R. China
Abstract
AbstractA versatile and readily available chiral amide directing group has been developed for the ruthenium(II)‐catalyzed asymmetric C−H activation. Asymmetric C−H activation of the related chiral benzamides with various olefins, aldehydes and propargylic alcohols has been accomplished with high stereoselectivities, affording a series of chiral products including 3,4‐dihydroisocoumarins (up to 96 % ee), isocoumarins (up to 92 % ee), phthalides (up to 99 % ee), chiral bicyclo[2.2.1]heptanes (>20 : 1 dr), 4‐alkylidene‐3,4‐dihydroisocoumarins (up to 97 % ee) and allenes (>20 : 1 dr). Importantly, our methodologies enabled concise syntheses of many biologically active compounds and natural products (e.g., Montroumarin, Cyclosporone E, Cyclosporone Q, Concentricolide, Chuangxinol, and Eleutherol).
Funder
Guangdong Provincial Key Laboratory of Construction Foundation
Subject
General Chemistry,Catalysis
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献