The Human Host‐Defense Peptide Cathelicidin LL‐37 is a Nanomolar Inhibitor of Amyloid Self‐Assembly of Islet Amyloid Polypeptide (IAPP)
Author:
Affiliation:
1. Division of Peptide Biochemistry TUM School of Life Sciences Emil-Erlenmeyer-Forum 5 85354 Freising Germany
2. Department of Bioengineering Stanford University 443 Via Ortega, Shriram Center for Bioengineering Stanford CA 94305 USA
Funder
Deutsche Forschungsgemeinschaft
Publisher
Wiley
Subject
General Chemistry,Catalysis
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202000148
Reference37 articles.
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3. IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans’ islets, directly initiates NLRP3 inflammasome activation
4. The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities
5. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
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