Varying the Stiffness and Diffusivity of Rod‐Shaped Microgels Independently through Their Molecular Building Blocks

Author:

Kittel Yonca123ORCID,Guerzoni Luis P. B.12ORCID,Itzin Carolina12,Rommel Dirk12ORCID,Mork Matthias12ORCID,Bastard Céline124ORCID,Häßel Bernhard12,Omidinia‐Anarkoli Abdolrahman12ORCID,Centeno Silvia P.1ORCID,Haraszti Tamás12ORCID,Kim Kyoohyun5ORCID,Guck Jochen5ORCID,Kuehne Alexander J. C.3ORCID,De Laporte Laura124ORCID

Affiliation:

1. DWI-Leibniz Institute for Interactive Materials e. V. Forckenbeckstraße 50 52074 Aachen Germany

2. Institute of Technical and Macromolecular Chemistry RWTH Aachen University Worringerweg 1–2 52074 Aachen Germany

3. Institute of Organic and Macromolecular Chemistry Ulm University Albert-Einstein Allee 11 89081 Ulm Germany

4. Center for Biohybrid Medical Systems (CBMS) Advanced Materials for Biomedicine (AMB) Institute of Applied Medical Engineering (AME) Forckenbeckstraße 55 52074 Aachen Germany

5. Max Planck Institute for the Science of Light and Max-Planck-Zentrum für Physik und Medizin Staudtstraße 2 91058 Erlangen Germany

Abstract

AbstractMicrogels are water‐swollen, crosslinked polymers that are widely used as colloidal building blocks in scaffold materials for tissue engineering and regenerative medicine. Microgels can be controlled in their stiffness, degree of swelling, and mesh size depending on their polymer architecture, crosslink density, and fabrication method—all of which influence their function and interaction with the environment. Currently, there is a lack of understanding of how the polymer composition influences the internal structure of soft microgels and how this morphology affects specific biomedical applications. In this report, we systematically vary the architecture and molar mass of polyethylene glycol‐acrylate (PEG‐Ac) precursors, as well as their concentration and combination, to gain insight in the different parameters that affect the internal structure of rod‐shaped microgels. We characterize the mechanical properties and diffusivity, as well as the conversion of acrylate groups during photopolymerization, in both bulk hydrogels and microgels produced from the PEG‐Ac precursors. Furthermore, we investigate cell‐microgel interaction, and we observe improved cell spreading on microgels with more accessible RGD peptide and with a stiffness in a range of 20 kPa to 50 kPa lead to better cell growth.

Funder

Deutsche Forschungsgemeinschaft

H2020 European Research Council

Publisher

Wiley

Subject

General Chemistry,Catalysis

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