Dose-dependent pharmacokinetics of toxic metabolites is not related to increased toxicity following high-dose valproic acid in rats

Author:

Jung Byung Hwa,Kim Bo Jun,Lee Min Sun,Lee Joo Hyun,Oh Ju-Hee,Lee Young-Joo

Publisher

Wiley

Subject

Toxicology

Reference20 articles.

1. Effect of valproate dose on formation of hepatotoxic metabolites;Anderson;Epilepsia,1992

2. Protein binding and hepatobiliary distribution of valproic acid and valproate glucuronide in rats;Brouwer;Biochem. Pharmacol.,1993

3. Critical evaluation of the potential error in pharmacokinetic studies of using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve;Chiou;J. Pharmacokinet. Biopharm.,1978

4. Early changes in hepatic redox homeostasis following treatment with a single dose of valproic acid;Cotariu;Biochem. Pharmacol,1990

5. Disposition of valproic acid in the rat: dose-dependent metabolism, distribution, enterohepatic recirculation and choleretic effect;Dickinson;J. Pharmacol. Exp. Ther.,1979

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