Dose-dependent pharmacokinetics of toxic metabolites is not related to increased toxicity following high-dose valproic acid in rats
Author:
Publisher
Wiley
Subject
Toxicology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/jat.1608/fullpdf
Reference20 articles.
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3. Critical evaluation of the potential error in pharmacokinetic studies of using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve;Chiou;J. Pharmacokinet. Biopharm.,1978
4. Early changes in hepatic redox homeostasis following treatment with a single dose of valproic acid;Cotariu;Biochem. Pharmacol,1990
5. Disposition of valproic acid in the rat: dose-dependent metabolism, distribution, enterohepatic recirculation and choleretic effect;Dickinson;J. Pharmacol. Exp. Ther.,1979
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