Single CpG hypermethylation, allele methylation errors, and decreased expression of multiple tumor suppressor genes in normal body cells of mutation‐negative early‐onset and high‐risk breast cancer patients

Author:

Böck Julia1,Appenzeller Silke2,Haertle Larissa1,Schneider Tamara1,Gehrig Andrea1,Schröder Jörg1,Rost Simone1,Wolf Beat34,Bartram Claus R.5,Sutter Christian5,Haaf Thomas1ORCID

Affiliation:

1. Institute of Human Genetics, University of WürzburgWürzburg Germany

2. Comprehensive Cancer Center, University HospitalWürzburg Germany

3. University of Applied Sciences Western SwitzerlandFribourg Switzerland

4. Department of BioinformaticsUniversity of WürzburgWürzburg Germany

5. Institute of Human Genetics, University HospitalHeidelberg Germany

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference47 articles.

1. Updates on breast cancer genetics: Clinical implications of detecting syndromes of inherited increased susceptibility to breast cancer

2. Genetic models of human cancer as a multistep process. Paradigm models of colorectal cancer, breast cancer, and chronic myelogenous and acute lymphoblastic leukaemia;Karakosta A;J Exp Clin Cancer Res.,2005

3. Cancer‐linked DNA hypomethylation and its relationship to hypermethylation;Ehrlich M.;Curr Top Microbiol Immunol.,2006

4. Gene Silencing in Cancer in Association with Promoter Hypermethylation

5. DNA repair and damage pathways in breast cancer development and therapy

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