Validated UHPLC–MS/MS method for simultaneous determination of four triterpene saponins from Akebia trifoliata extract in rat plasma and its application to a pharmacokinetic study

Author:

Chen Weikang1ORCID,Zheng Yangbin1,Yan Liang1,Yuan Mingming1,Ouyang Lan2,Li Jun3,Zhou Guoping12,Zhong Ruijian1

Affiliation:

1. Jiangxi Institute for Drug Control/Jiangxi Engineering Research Center for Drug and Medical Device Quality Nanchang China

2. School of PharmacyNanchang University Nanchang China

3. Jiangxi University of Traditional Chinese Medicine Nanchang China

Funder

Key Research and Development Program of Jiangxi Province

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference24 articles.

1. DHHS FDA CDER & CBER. (2018).Analytical Procedures and Methods Validation for Drugs and Biologics.https://www.fda.gov/downloads/drugs/guidances/ucm386366.pdf.

2. A new triterpenoid saponin from stems of Akebia trifoliata;Gao H. M.;Acta Pharmaceutica Sinica,2006

3. Triterpenoid saponins and phenylethanoid glycosides from stem of Akebia trifoliata var. australis

4. Determination of saponins in Akebia trifoliata by RP‐HPLC;Gao H. M.;Chinese Pharmaceutical Journal,2007

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