PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease

Author:

Schmidt Amand F1,Pearce Lucy S2,Wilkins John T3,Overington John P4,Hingorani Aroon D1,Casas Juan P5

Affiliation:

1. University College London; Institute of Cardiovascular Science; 222 Euston Road, Room 206 London UK NW1 2DA

2. London School of Hygiene & Tropical Medicine; Department of Non-communicable Disease Epidemiology; Keppel Street London UK WC1 E7HT

3. Northwestern University Feinberg School of Medicine; The Department of Medicine (Cardiology) and the Department of Preventive Medicine; Suite 1400 680 N. Lakeshore Drive Chicago Illinois USA 60611

4. Medicines Discovery Catapult; 40 Churchway Alderly Edge UK SK10 4TG

5. University College London; Farr Institute of Health Informatics Research; 222 Euston Road London UK NW1 2DA

Publisher

Wiley

Subject

Pharmacology (medical)

Reference111 articles.

1. Results of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, from a randomized, placebo-controlled, dose-ranging study in statin-treated subjects with hypercholesterolemia;Ballantyne;American Journal of Cardiology,2015

2. A 52-week placebo-controlled trial of evolocumab in hyperlipidemia;Blom;New England Journal of Medicine,2014

3. Tingley W Mosesova S Baruch A Davis JD Budha N Vilimovskij A Effects of RG7652, a monoclonal antibody against proprotein convertase Subtilisin/Kexin type 9, on LDL cholesterol in patients with coronary heart disease or high risk: results from the EQUATOR study European Heart Journal 2014 371

4. Evolocumab and clinical outcomes in patients with cardiovascular disease;Sabatine;New England Journal of Medicine,2017

5. Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin rechallenge arm: the ODYSSEY ALTERNATIVE randomized trial;Moriarty;Journal of Clinical Lipidology,2015

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