Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation

Author:

Estcourt Lise J1,Stanworth Simon J2,Doree Carolyn3,Hopewell Sally4,Trivella Marialena4,Murphy Michael F5

Affiliation:

1. NHS Blood and Transplant; Haematology/Transfusion Medicine; Level 2, John Radcliffe Hospital Headington Oxford UK OX3 9BQ

2. Oxford University Hospitals NHS Foundation Trust and the University of Oxford; National Institute for Health Research (NIHR) Oxford Biomedical Research Centre; John Radcliffe Hospital, Headley Way Headington Oxford UK OX3 9BQ

3. NHS Blood and Transplant; Systematic Review Initiative; John Radcliffe Hospital Oxford UK OX3 9BQ

4. University of Oxford; Centre for Statistics in Medicine; Wolfson College Linton Road Oxford Oxfordshire UK OX2 6UD

5. Oxford University Hospitals and the University of Oxford; NHS Blood and Transplant; National Institute for Health Research (NIHR) Oxford Biomedical Research Centre; John Radcliffe Hospital Headington Oxford UK

Publisher

Wiley

Subject

Pharmacology (medical)

Reference302 articles.

1. A prospective randomised trial of a prophylactic platelet transfusion trigger of 10 x 109 per L versus 30 x 109 per L in allogeneic hematopoietic progenitor cell transplant recipients;Diedrich;Transfusion,2005

2. Randomized evaluation of the optimal platelet count for prophylactic platelet transfusions in patients undergoing induction therapy for acute leukaemia (American Society of Hematology 35th Annual Meeting);Heckman;Blood,1993

3. Randomized study of prophylactic platelet transfusion threshold during induction therapy for adult acute leukaemia: 10 x 109/L versus 20 x 109/L;Heckman;Journal of Clinical Oncology,1997

4. Methods for the analysis of bleeding outcomes in randomised trials of platelet transfusion triggers;Cook;Transfusion,2004

5. The platelet transfusion trigger trial (PTTT): A multivariate analysis of risk factors for major bleeding in acute myeloid leukaemia (AML);Finazzi G for the GIMEMA Group;Thrombosis and Haemostasis,1997

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