Effectiveness of dolutegravir‐based regimens as either first‐line or switch antiretroviral therapy: data from the Icona cohort

Author:

Mondi Annalisa1ORCID,Cozzi‐Lepri Alessandro2,Tavelli Alessandro3,Rusconi Stefano4,Vichi Francesca5,Ceccherini‐Silberstein Francesca6,Calcagno Andrea7,De Luca Andrea8,Maggiolo Franco9,Marchetti Giulia10,Antinori Andrea1,d'Arminio Monforte Antonella10,Andreoni M,Castagna A,Castelli F,Cauda R,Di Perri G,Galli M,Iardino R,Ippolito G,azzarin A,Rezza G,Schloesser F,Viale P,Ceccherini‐Silberstein F,Cozzi‐Lepri A,Girardi E,Lo Caputo S,Mussini C,Puoti M,Perno CF,Balotta C,Bandera A,Bonora S,Borderi M,Capetti A,Capobianchi MR,Cicalini S,Cingolani A,Cinque P,Di Biagio A,Gianotti N,Gori A,Guaraldi G,Lapadula G,Lichtner M,Madeddu G,Maggiolo F,Monno L,Nozza S,Quiros Roldan E,Rossotti R,Rusconi S,Santoro MM,aracino A,Sarmati L,Fanti I,Galli L,Lorenzini P,Rodano’ A,Macchia M,Tavelli A,Carletti F,Carrara S,Di Caro A,Graziano S,Petrone F,Prota G,Quartu S,Truffa S,Giacometti Italy A,Costantini A,Barocci V,Angarano G,Fabrizio C,Suardi C,i V,Verucchi G,Castelnuovo F,Minardi C,Menzaghi B,Abeli C,Cacopardo B,Celesia B,Vecchiet J,Falasca K,Pan A,Lorenzotti S,Sighinolfi L,Segala D,Blanc P,Cassola G,Viscoli C,lessandrini A,Bobbio N,Mazzarello G,Pozzetto I,Bonfanti P,Molteni C,Chiodera A,Milini P,Nunnari G,Pellicanò G,Rizzardini G,Bai F,Moioli MC,Piolini R,Ridolfo AL,Salpietro S,Tincati C,Puzzolante C,Migliorino C,Sangiovanni V,Borgia G,Esposito V,Di Martino F,Gentile I,Maddaloni L,Cattelan AM,Marinello S,Cascio A,Colomba C,Baldelli F,Schiaroli E,Parruti G,Sozio F,Magnani G,Ursitti MA,Cristaudo A,Vullo V,Acinapura R,Baldin G,Capozzi M,Rivano Capparucia M,Iaiani G,atini A,Mastrorosa I,Plazzi MM,Savinelli S,Vergori A,Cecchetto M,Viviani F,Bagella P,Rossetti B,Fontana Del Vecchio R,Francisci D,Di Giuli C,Caramello P,Orofino GC,Sciandra M,Bassetti M,ondero A,Pellizzer G,Manfrin V,Starnini G,alungo A,

Affiliation:

1. HIV/AIDS Department National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS Rome Italy

2. Institute for Global Health University College London London UK

3. Icona Foundation Milan Italy

4. Infectious Diseases Unit ASST FBF‐Sacco, DIBIC “L. Sacco” University of Milan Milan Italy

5. Unit of Infectious Diseases Santa Maria Annunziata Hospital Firenze Italy

6. Department of Experimental Medicine and Surgery University of Rome Tor Vergata Rome Italy

7. Unit of Infectious Diseases Department of Medical Sciences Amedeo di Savoia Hospital University of Torino Turin Italy

8. Infectious Diseases Unit University of Siena Siena Italy

9. Unit of Infectious Diseases ASST‐PG23 Bergamo Italy

10. Clinic of Infectious and Tropical Diseases Department of Health Sciences ASST Santi Paolo e Carlo University of Milan Milan Italy

Funder

ViiV Healthcare

Gilead Sciences

Bristol-Myers Squibb

Merck Sharp and Dohme

Publisher

Wiley

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health

Reference30 articles.

1. Panel on Antiretroviral Guidelines for Adults and Adolescents.Guidelines for the use of antiretroviral agents in HIV‐1‐infected adults and adolescents.Department of Health and Human Services;2017. [cited 12 Dec 2017]. Available from:https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf

2. World Health Organization.Updated recommendations on first‐line and second‐line antiretroviral regimens and post‐exposure prophylaxis and recommendations on early infant diagnosis of hiv. HIV treatment‐interim guidance. [cited 11 Oct 2018]. Available from:http://apps.who.int/iris/bitstream/handle/10665/273632/WHO-CDS-HIV-18.18-eng.pdf?ua=1

3. Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study

4. Dolutegravir plus Abacavir–Lamivudine for the Treatment of HIV-1 Infection

5. Once-daily dolutegravir versus darunavir plus ritonavir in antiretroviral-naive adults with HIV-1 infection (FLAMINGO): 48 week results from the randomised open-label phase 3b study

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