A phase I trial of metformin in combination with vincristine, irinotecan, and temozolomide in children with relapsed or refractory solid and central nervous system tumors: A report from the national pediatric cancer foundation

Author:

Metts Jonathan L.1ORCID,Trucco Matteo2,Weiser Daniel A.3ORCID,Thompson Patrick4,Sandler Eric5,Smith Tiffany6,Crimella Jessica7,Sansil Samer8ORCID,Thapa Ram9,Fridley Brooke L.9,Llosa Nicholas10,Badgett Thomas11,Gorlick Richard12,Reed Damon13ORCID,Gill Jonathan12

Affiliation:

1. Cancer and Blood Disorders Institute Johns Hopkins All Children's Hospital St Petersburg Florida USA

2. Cleveland Clinic Children's Hospital Department of Pediatric Hematology‐Oncology & Bone Marrow Transplantation Cleveland Ohio USA

3. Departments of Pediatrics and Genetics, Montefiore Medical Center Albert Einstein College of Medicine Bronx New York USA

4. Division of Pediatric Hematology‐Oncology University of North Carolina Health Care Chapel Hill North Carolina USA

5. Department of Pediatric Oncology Nemours Health Systems Jacksonville Florida USA

6. Cognitive Research Corporation St Petersburg Florida USA

7. Clinical Trials Office Partnerships H. Lee Moffitt Cancer Center and Research Institute Tampa Florida USA

8. Cancer Pharmacokinetics and Pharmacodynamic Core H. Lee Moffitt Cancer Center and Research Institute Tampa Florida USA

9. Department of Biostatistics and Bioinformatics H. Lee Moffitt Cancer Center and Research Institute Tampa Florida USA

10. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine Baltimore Maryland USA

11. Department of Pediatrics University of Kentucky College of Medicine Lexington Kentucky USA

12. Department of Pediatrics University of Texas MD Anderson Cancer Center Houston Texas USA

13. Adolescent and Young Adult Program, Department of Interdisciplinary Cancer Management H. Lee Moffitt Cancer Center Tampa Florida USA

Funder

Rally Foundation

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

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