Improving the capturing ability of swirl‐based microfluidic chip by introducing baffle wall

Abstract

AbstractMicrofluidics technology is promising in developing microparticle manipulation technology due to its nondestructive control and notable adaptability. The manipulation of microparticle based on swirling stagnation point is one of the feasible microfluidics biotechnologies. Aiming to improve the regulation and control of microparticle, baffle wall is introduced into the 2‐microchannel flow field. The theory of wall attachment jet is employed to elucidate the effect of baffle wall. Subsequently, finite volume method simulation is conducted by modeling the swirling flow region (SFR), and the swirling strength is calculated to characterize the SFR's particle‐capturing ability. Experimental validation of the modeling and simulation methods is performed using a printed microfluidic chip, which has demonstrated exceptional reliability. Simulation results show that the baffle wall makes considerable influence on the SFR. Strikingly, a global range adjustment of stagnation point is realized when the baffle wall is configured with a convex shape, which has remarkably outperformed our previous work, where the stagnation point could only move within half range of the field. This work significantly contributes to advanced flow field structure and provides insight into better regulation of stagnation point as well as microparticles. These findings have potential applications in the analysis of the effect of bio/chemical substances on single cell.