Inhibition of the NLRP3/IL‐1β axis protects against sepsis‐induced cardiomyopathy

Author:

Busch Katharina1,Kny Melanie1,Huang Nora12,Klassert Tilman E.34,Stock Magdalena34,Hahn Alexander1,Graeger Sebastian5,Todiras Mihail67,Schmidt Sibylle1,Chamling Bishwas58,Willenbrock Michael9,Groß Stefan58,Biedenweg Doreen510,Heuser Arnd11,Scheidereit Claus9,Butter Christian2,Felix Stephan B.58,Otto Oliver510,Luft Friedrich C.1,Slevogt Hortense34,Fielitz Jens158ORCID

Affiliation:

1. Experimental and Clinical Research Center (ECRC), Charité‐Universitätsmedizin Berlin, Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association Berlin Germany

2. Department of Cardiology Heart Center Brandenburg and Medical School Brandenburg (MHB) Bernau Germany

3. ZIK Septomics, Host Septomics Jena Germany

4. Jena University Hospital, Integrated Research and Treatment Center ‐ Center for Sepsis Control and Care (CSCC) Jena Germany

5. DZHK (German Center for Cardiovascular Research), Partner Site Greifswald Greifswald Germany

6. Laboratory of Molecular Biology of Peptide Hormones Max Delbrück Center for Molecular Medicine Berlin Germany

7. Nicolae Testemiţanu State University of Medicine and Pharmacy Chișinău Moldova

8. Department of Internal Medicine B, Molecular Cardiology University Medicine Greifswald Greifswald Germany

9. Signal Transduction in Development and Cancer Max Delbrück Center for Molecular Medicine Berlin Germany

10. Centre for Innovation Competence ‐ Humoral Immune Response in Cardiovascular Diseases University of Greifswald Greifswald Germany

11. Animal Phenotyping Facility Max Delbrück Center for Molecular Medicine Berlin Germany

Funder

Bundesministerium für Bildung und Forschung

Deutsches Zentrum für Herz-Kreislaufforschung

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Physiology (medical),Orthopedics and Sports Medicine

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