UPLC-MS/MS assay for the simultaneous quantification of carvedilol and its active metabolite 4′-hydroxyphenyl carvedilol in human plasma to support a bioequivalence study in healthy volunteers

Author:

Patel Daxesh P.1,Sharma Primal1,Sanyal Mallika2,Singhal Puran3,Shrivastav Pranav S.1

Affiliation:

1. Department of Chemistry, School of Sciences; Gujarat University; Ahmedabad; 380009; Gujarat; India

2. Department of Chemistry; St. Xavier's College; Navrangpura; Ahmedabad; 380009; Gujarat; India

3. Alkem Laboratories Ltd; MIDC Ind Estate, Taloja (MIDC); Navi Mumbai; Maharashtra; 410208; India

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference41 articles.

1. Determination of carvedilol in human cardiac tissue by high-performance liquid chromatography;Behn;Journal of Chromatographic Science,2001a

2. HPLC quantification of carvedilol in small plasma volumes from children;Behn;Chromatographia,2001b

3. Quantification of carvedilol in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry: application to bioequivalence study;Borges;Journal of Chromatography B,2005

4. Clinical updates on carvedilol: a first choice beta-blocker in the treatment of cardiovascular diseases;Chakraborty;Expert Opinion on Drug Metabolism & Toxicology,2010

5. High-throughput liquid chromatography-tandem mass spectrometric method for simultaneous quantification of carvedilol and its metabolite 4′-hydroxyphenyl carvedilol in human plasma and its application to bioequivalence study;Chandiran;Journal of Chemical and Pharmaceutical Research,2011

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