Affiliation:
1. Department of Basic Sciences Shanxi Agricultural University Taigu Shanxi 030801 People's Republic of China
2. School of Pharmacy China Pharmaceutical University Nanjing 210009 People's Republic of China
3. Department of Chemistry Nankai University Tianjin 300071 People's Republic of China
4. College of Agronomy Shanxi Agricultural University Taigu Shanxi 030801 People's Republic of China
Abstract
Three new dinuclear Co(II) complexes [Co2(L1)2Cl2](PF6)2 (1), [Co2L2(OAc)2(CH3OH)4](ClO4)2 (2), and [Co2L3(OAc)2(CH3OH)4](ClO4)2 (3) were synthesized and structurally determined by X‐ray single‐crystal diffraction analysis as well as IR, elemental analysis, and mass spectrometry. All complexes exhibit efficiently self‐activated cleavage activity with hydrolytic mechanism, which was accurately proved by addition of regular radical scavengers, anaerobic cleavage experiment, and 2‐thiobarbituric acid reaction. Complex 1 exhibited higher selective cytotoxicity against tumor cells than normal cells, which is significantly better than that of cisplatin. Hoechst 33342 staining, intracellular ROS generation and mitochondrial membrane potential were conducted to assess the apoptosis‐inducing activity of 1. The effect of complex 1 on cell invasion was observed by Transwell assay and angiogenesis experiment, and the results demonstrated that 1 could inhibit the cell invasion and angiogenesis.
Funder
Natural Science Foundation of Shanxi Province
National Key Research and Development Program of China
Subject
Inorganic Chemistry,General Chemistry