Novel therapeutic roles of MC-4 in combination with everolimus against advanced renal cell carcinoma by dual targeting of Akt/pyruvate kinase muscle isozyme M2 and mechanistic target of rapamycin complex 1 pathways

Author:

Son Ji Yeon1,Yoon Sungpil1,Tae In Hwan1,Park Yu Jin1,De Umasankar1,Jeon Yukyoung1,Park Young Ju1,Rhyu Im Joo2,Lee Byung Mu1,Chung Kyu-Huck1,Lim Joung Eun3,Lee Se Jeong2,Lee Hye Won345ORCID,Kwak Jong Hwan1,Kim Hyung Sik1,Choi Han Yong6

Affiliation:

1. School of Pharmacy; Sungkyunkwan University; Suwon Korea

2. Department of Anatomy; Korea University College of Medicine; Seoul Korea

3. Departments of Urology; Samsung Medical Center; Sungkyunkwan University School of Medicine; Seoul Korea

4. Department of Anatomy and Cell Biology; Sungkyunkwan University School of Medicine; Suwon Korea

5. Single Cell Network Research Center; Sungkyunkwan University School of Medicine; Suwon Korea

6. Department of Urology; Kangbuk Samsung Hospital; Seoul Korea

Funder

National Research Foundation of Korea

Ministry of Science, ICT and Future Planning

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

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