Affiliation:
1. Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 China
2. Institute of Structural Pharmacology & TCM Chemical Biology, College of Pharmacy Fujian University of Traditional Chinese Medicine Fuzhou 350122 China
Abstract
AbstractThree new labdane‐type diterpenoids, calcaratarin E, villosumtriol, and 12‐epi‐villosumtriol (1–3) were isolated from the fruits of Amomum villosum, along with seven known diterpenoids (4–10). Through comprehensive analysis of chemical evidence and spectral data including UV, 1D and 2D NMR, HR‐ESI‐MS, IR, and X‐ray crystallography, the structures of these novel compounds were successfully determined. Additionally, the inhibitory effects of compounds 2–10 on NO production in lipopolysaccharide (LPS)‐induced RAW264.7 cells were evaluated. Notably, compound 6 exhibited the most significant inhibitory effect with an IC50 value of 1.74±0.69 μM.
Funder
China Postdoctoral Science Foundation
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
Cited by
1 articles.
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