Four New Polyhydroxy Cyclohexanes from the Stems of <i>Fissistigma tientangense</i>-Reference-Cited by-同舟云学术

Four New Polyhydroxy Cyclohexanes from the Stems of Fissistigma tientangense

Published:2023-04-26 Issue:5 Volume:20 Page:
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chemistry & Biodiversity

Author:

Wu Mei‐Zhu¹²,Chen Ming‐Chang¹²,Zhang Xiao‐Zheng¹²,Sun Chen¹²,Chen Guang‐Ying¹²,Yang Zi‐Han¹²,Zheng Cai‐Juan¹²,Luo You‐Ping¹²,Zhou Xue‐Ming¹²^ORCID

Affiliation:

1. Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education College of Chemistry and Chemical Engineering Hainan Normal University Haikou 571158 China

2. Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province College of Chemistry and Chemical Engineering Hainan Normal University Haikou 571158 China

Abstract

AbstractFour undescribed polyhydroxy cyclohexanes, fissoxhydrylenes A–D (1–4), together with two known biogenetically related polyhydroxy cyclohexanes (5 and 6) were isolated from the stems of Fissistigma tientangense Tsiang et P. T. Li. Their structures were elucidated by detailed analysis of NMR, HR‐ESI‐MS, IR, UV and Optical rotations data. The absolute configuration of 1 was confirmed by X‐ray crystallographic. The absolute configurations of 2–4 were confirmed by chemical reaction and optical rotations. Compound 4 represent the first example of a no substituent polyhydroxy cyclohexanes from natural products. All isolated compounds were evaluated for their anti‐inflammatory activities against the lipopolysaccharide‐induced nitric oxide (NO) production in mouse macrophage RAW 264.7 cells in vitro. Compounds 3 and 4 showed inhibitory activities with the IC50 values of 16.63±0.06 μM and 14.38±0.08 μM, respectively.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202300330

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