Affiliation:
1. School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University 110016 Shenyang China
2. State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and Toxicology 100850 Beijing China
3. State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of Sciences 100101 Beijing China
Abstract
AbstractA new polyaromatic metabolite, ent‐herqueidiketal (1), and a new phenalenone derivative, epi‐peniciherqueinone (2), along with twelve known compounds 3–14, were isolated from the fungus Penicillium herquei YNJ‐35, a symbiotic fungus of Pulveroboletus brunneopunctatus collected from Nangunhe Nature Reserve, Yunnan Province, China. The structures of 1–14 and the absolute configurations of 1 and 2 were determined by their spectroscopic data or by their single‐crystal X‐ray diffraction analysis or optical rotation values. Compound 1 showed strong antibacterial activity against Staphylococcus aureus (ATCC 29213) with minimum inhibitory concentration (MIC) of 8 μg/mL. In the cytotoxicity assays, compound 1 showed weak inhibitory activity against breast cancer MCF‐7 and mice microglial BV2 cells with half maximal inhibitory concentration (IC50) of 17.58 and 29.56 μM; compound 14 showed stronger cytotoxicity against BV2 and MCF‐7 cells with IC50 values of 6.57 and 10.26 μM.
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering