Four New Stilbene Derivatives Isolated from <i>Gnetum latifolium</i> var. <i>funiculare</i> Markgr. and Their Inhibition of NO Production in LPS‐activated RAW264.7 Cells-Reference-Cited by-同舟云学术

Four New Stilbene Derivatives Isolated from Gnetum latifolium var. funiculare Markgr. and Their Inhibition of NO Production in LPS‐activated RAW264.7 Cells

Published:2023-10 Issue:10 Volume:20 Page:
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chemistry & Biodiversity

Author:

Thuy Trinh Thi¹²,Hoa Nguyen Thi Thu¹³,Linh Nguyen Thi Thuy¹²,Cham Ba Thi¹²,Anh Nguyen Thi Hoang¹²,Hiep Nguyen Tuan⁴,Adorisio Sabrina⁵,Delfino Domenico V⁵,Bang Ngo Anh⁶,Tai Bui Huu¹⁶,Kiem Phan Van¹⁶^ORCID

Affiliation:

1. Graduate University of Science and Technology VAST 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam

2. Institute of Chemistry Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam

3. Vietnam National University of Agriculture Trau Quy, Gia Lam Hanoi 10072 Vietnam

4. National Institute of Medicinal Materials 3B Quang Trung Hoan Kiem 10072 Vietnam

5. Master in musculoskeletal and rheumatology physiotherapy Department of Medicine and Surgery University of Perugia Piazzale Severi, S. Andreadelle Fratte 06132 Perugia Italy

6. Institute of Marine Biochemistry VAST 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam E-mail: s

Abstract

AbstractGnetum latifolium var. funiculare Markgr. is a medicinal plant and widely distributed in mountainous areas of Vietnam. Phytochemical investigation on the trunks of this plant afforded eight stilbene derivatives (1–8) including for new compounds (1–4). Their structures were determined based on extensive analyses of HR‐ESI‐MS, 1D and 2D NMR spectra. Among the isolates, compounds 1–3 showed moderate NO production inhibition in LPS‐activated RAW264.7 cells with the IC50 values ranging from 46.81 to 68.10 μM, compounds 4 and 6 showed weak effects with the IC50 values of 96.57 and 79.46 μM, respectively, compared to that of the positive control compound, dexamethasone (IC50 14.20 μM).

Funder

National Foundation for Science and Technology Development

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202301166

Reference15 articles.

1. Oligostilbenes from the leaves of Gnetum latifolium and their biological potential to inhibit neuroinflammation

2. Stilbenoids from the stem of Gnetum latifolium (Gnetaceae)

3. Antiplasmodial activity of novel stilbene derivatives isolated from Parthenocissus tricuspidata from South Korea

4. Rapid Chemical Characterisation of Stilbenes in the Root Bark of Norway Spruce by Off-line HPLC/DAD-NMR