Alkaloids and Lignans from the Aerial Parts of Rauvolfia tetraphylla Inhibit NO Production in LPS‐activated RAW 264.7 Cells

Author:

Tung Ninh Khac Thanh12,Dung Duong Thi3,Kiem Phan Van34,Hang Dan Thi Thuy3,Nhiem Nguyen Xuan34,The Nguyen Van5,Seo Yohan6,Kang Jong Seong1,Tai Bui Huu34ORCID

Affiliation:

1. College of Pharmacy Chungnam National University Daejeon 305-764 Korea

2. Center for High Technology Research and Development VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam

3. Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam

4. Graduate University of Science and Technology, VAST 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam

5. Traditional Medicine Hospital of Public Security Ministry of Vietnam Hanoi 10000 Vietnam

6. New Drug Development Center Daegu-Gyeongbuk Medical Innovation Foundation (KMEDIhub 88 Dongnae-ro, Dong-gu Daegu Korea

Abstract

AbstractThree previously undescribed compounds named rauvolphyllas A−C (1‐3), along with thirteen known compounds, 18β‐hydroxy‐3‐epi‐α‐yohimbine (4), yohimbine (5), α‐yohimbine (6), 17‐epi‐α‐yohimbine (7), (E)‐vallesiachotamine (8), (Z)‐vallesiachotamine (9), 16SE‐isositsirikine (10), Nb–methylisoajimaline (11), Nb–methylajimaline (12), ajimaline (13), (+)‐lyoniresinol 3α‐Oβ‐D‐glucopyranoside (14), (+)‐isolarisiresinol 3α‐Oβ‐D‐glucopyranoside (15), and (−)‐lyoniresinol 3α‐Oβ‐D‐glucopyranoside (16) were isolated from the aerial parts of Rauvolfia tetraphylla L. Their chemical structures were elucidated based on the extensive spectroscopic interpretation of HR‐ESI‐MS, 1D and 2D NMR spectra. The absolute configurations of 2 and 3 were determined by experimental ECD spectra. Compounds 5, 6, 7, and 1113 exhibited nitric oxide production inhibition activity in LPS‐activated RAW 264.7 cells with the IC50 values of 79.10, 44.34, 51.28, 33.54, 37.67, and 28.56 μM, respectively, compared to that of the positive control, dexamethasone, which showed IC50 value of 13.66 μM. The other isolates were inactive with IC50 values over 100 μM.

Funder

Vietnam Academy of Science and Technology

Publisher

Wiley

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