Affiliation:
1. Department of Marine Biomedicine and Polar Medicine Naval Medical Center of PLA Naval Medical University Shanghai 200433 China
2. Department of Dermatology Naval Medical Center of PLA Naval Medical University Shanghai 200052 China
3. Department of Biochemistry and Molecular Biology College of Basic Medical Sciences Naval Medical University Shanghai 200433 China
Abstract
AbstractTwo uncommon epoxyquinols, pyrrolocytosporin A (1) and cytosporin E2 (2), along with the known cytosporin Y1 (3), were isolated from the solid defined medium of the Arctic‐derived fungus Eutypella sp. D‐1. Their structures were established through comprehensive analyses of spectroscopic and electronic circular dichroism data. Structurally, compound 1 represented the first nitrogen‐containing epoxyquinol characterized by a pyrrole fused cytosporin framework, while compound 2 contained an uncommon cyclic carbonate functionality. The antibacterial, immunosuppressive, anti‐inflammatory, and cytotoxic activities of all compounds were evaluated. Among the three metabolites, only compound 1 exhibited inhibitory effects on nitric oxide production induced by lipopolysaccharide with an IC50 value of 6.55 μM. Additionally, only compound 2 displayed inhibitory activity against ConA‐induced T‐cell proliferation with an IC50 value of 9.85 μM.