Affiliation:
1. School of chemistry biology and environment Vinh University 182 Le Duan, Ben Thuy Vinh City Nghe An 461010 Vietnam
2. Institute of Marine Biochemistry VAST 18 Hoang Quoc Viet Cau Giay Hanoi 10072 Vietnam
3. Institute of Ecology and Biological Resources VAST, 18 Hoang Quoc Viet Cau Giay Hanoi 10072 Vietnam
4. Department of Chemistry Vinh University, 182 Le Duan, Ben Thuy Vinh City Nghe An 461010 Vietnam
Abstract
AbstractFour undescribed spirostan glycosides, (25S)‐5α‐spirostan‐ 12‐one‐2α,3β‐diol‐3‐O‐β‐D‐glucopyranosyl‐(1→4)‐β‐D‐galactopyranoside (1), (25S)‐5α‐spirostan‐12‐one‐2α,3β‐diol‐3‐O‐β‐D‐galatopyranosyl‐(1→2)‐β‐D‐glucopyranosyl‐ (1→4)‐β‐D‐galactopyranoside (2), (25S)‐5α‐spirostan‐12‐one‐2α,3β‐diol‐3‐O‐β‐D‐glucopyranosyl‐(1→2)‐[β‐D‐glucopyranosyl‐(1→3)]‐β‐D‐glucopyranosyl‐(1→4)‐β‐D‐galactopyranoside (3), and hecogenin 3‐O‐β‐D‐glucopyranosyl‐(1→3)‐[β‐D‐xylopyranosyl‐(1→2)]‐β‐D‐glucopyranosyl‐(1→4)‐[α‐L‐rhamnopyranosyl‐(1→2)]‐β‐D‐galactopyranoside (4), together with eleven known compounds (5–15) were isolated from the branches and leaves of Tribulus terrestris. Their chemical structures were established through spectroscopic methods, including HR‐ESI‐MS, 1D‐, and 2D‐NMR spectra. Preliminary biological evaluation on NO production inhibitory activity in LPS activated RAW 264.7 cells showed that compounds 1–3, 5, and 6 had significant inhibitory effects with IC50 values ranging from 2.4 to 18.3 μM, compared to that of the positive control compound, dexamethazone (IC50 13.6 μM).
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