Affiliation:
1. School of Pharmacy Henan University of Chinese Medicine Zhengzhou 450046 China
2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province Zhengzhou 450046 China
3. Academy of Chinese Medical Sciences Henan University of Chinese Medicine Zhengzhou 450046 China
4. Co-construction of Collaborative Innovation Center for Chinese Medicine Respiratory Diseases by Henan & Education Ministry Zhengzhou 450046 China
Abstract
AbstractThe phytochemical investigation of the fruits of Cornus officinalis yielded a new phenolic acid derivative, neophenolic acid A (1), and a novel flavonoid glycoside, (2R)‐naringenin‐7‐O‐β‐(6′′‐galloyl‐glucopyranoside) (2 a), along with six known flavonoid glycosides (2 b–7). Their structures were determined by 1D, 2D NMR and HRESIMS data. The absolute configuration of 1 was established by ECD analysis. Compounds 1– 7 were evaluated for their neuroprotective activities against corticosterone (CORT)‐induced injury in PC‐12 cells. Compounds 1, 2 a, 2 b, 5, and 6 exhibited neuroprotective activities against CORT‐induced neurotoxicity in PC‐12 cells. The underlying mechanism study suggested that compounds 1, 2 a, 2 b, 5, and 6 were able to attenuate CORT‐induced apoptosis and damage, increase the levels of MMP and decrease Ca2+ inward flow in PC‐12 cells.