Five New Furostanol Glycosides from the Fruits of Tribulus terrestris with NO Production Inhibitory Activity

Author:

Kiem Phan Van1ORCID,Quoc Nguyen Van2,Tai Bui Huu1,Yen Pham Hai1,Huy Hoang Nguyen1,Thi Thuy Hang Dan1,Huong Phan Thi Thanh1,Anh Bang Ngo1,Dung Duong Thi1,Trang Do Thi1,Giang Le Duc3

Affiliation:

1. Institute of Marine Biochemistry VAST 18 Hoang Quoc Viet Cau Giay, Hanoi 10072 Vietnam

2. School of Chemistry Biology and Environment Vinh University 182 Le Duan Ben Thuy, Vinh City Nghe An 461010 Vietnam

3. Department of Chemistry Vinh University 182 Le Duan Ben Thuy, Vinh City Nghe An 461010 Vietnam

Abstract

AbstractEight furostanol glycosides including five undescribed compounds, named tribufurostanosides A–E (15), and three known ones (68) were isolated from the fruits of Tribulus terrestris L. Their chemical structures were determined by the IR, HR‐ESI‐MS, 1D‐, and 2D‐NMR spectra. Furostanols 1–8 significantly inhibited nitric oxide production in LPS activated RAW 264.7 cells with IC50 values ranging from 14.2 to 64.7 μM, compared to that of the positive control compound, dexamethazone (IC50 13.6 μM).

Publisher

Wiley

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