Affiliation:
1. Pharmacy College of Changchun University of Chinese Medicine Changchun 130117 China
2. Pharmacy College of Chengdu University of Traditional Chinese Medicine Chengdu 611137 China
Abstract
AbstractThis study investigated the effect of butanol extract of AS (ASBUE) on atherosclerosis in apolipoprotein E‐deficient (ApoE−/−) mice. The mice were administered ASBUE (390 or 130 mg/kg/day) or rosuvastatin (RSV) via oral gavage for eight weeks. In ApoE−/− mice, ASBUE suppressed the abnormal body weight gain and improved serum and liver biochemical indicators. ASBUE remarkably reduced the aortic plaque area, improved liver pathological conditions, and lipid metabolism abnormalities, and altered the intestinal microbiota structure in ApoE−/− mice. In the vascular tissue of ASBUE‐treated mice, P‐IKKβ, P‐NFκB, and P‐IκBα levels tended to decrease, while IκB‐α increased in high fat‐diet‐fed atherosclerotic mice. These findings demonstrated the anti‐atherosclerotic potential of ASBUE, which is mediated by the interaction between the gut microbiota and lipid metabolism and regulated via the Nuclear Factor‐kappa B (NF‐κB) pathway. This work paves the groundwork for subsequent studies to develop innovative drugs to treat atherosclerosis.
Funder
Department of Science and Technology of Jilin Province
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
Cited by
2 articles.
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