Establishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathway-Reference-Cited by-同舟云学术

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Establishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathway

Published:2016-07-06 Issue:9 Volume:60 Page:1967-1983
ISSN:1613-4125
Container-title:Molecular Nutrition & Food Research
language:en
Short-container-title:Mol. Nutr. Food Res.

Author:

Wang Meifang¹²,Yang Guangyi¹²³,He Yu²,Xu Beibei²,Zeng Min¹²,Ge Shufan²,Yin Taijun²,Gao Song¹²,Hu Ming¹²

Affiliation:

1. Hubei University of Medicine and University-Affiliated Taihe Hospital; Shiyan China

2. Department of Pharmacological and Pharmaceutical Sciences; College of Pharmacy; University of Houston; Houston TX, USA

3. Hubei Provincial Technology and Research Center for Comprehensive Development of Medicinal Herbs; Hubei University of Medicine; Shiyan Hubei China

Funder

National Institutes of Health

Taihe Hospital

Hubei University of Medicine

Publisher

Wiley

Subject

Food Science,Biotechnology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/mnfr.201500321/fullpdf

Reference31 articles.

1. UDP-glucuronyltransferases in detoxification and activation metabolism of endogenous compounds and xenobiotics];Fedejko;Postepy Biochem,2011

2. Revolving door action of breast cancer resistance protein (BCRP) facilitates or controls the efflux of flavone glucuronides from UGT1A9-overexpressing HeLa cells;Wei;Mol. Pharm.,2013

3. Three-dimensional quantitative structure-activity relationship studies on UGT1A9-mediated 3-O-glucuronidation of natural flavonols using a pharmacophore-based comparative molecular field analysis model;Wu;J. Pharmacol. Exp. Ther.,2011

4. A historical overview of the heterologous expression of mammalian UDP-glucuronosyltransferase isoforms over the past twenty years;Radominska-Pandya;Curr. Drug Metab,2005

5. First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics;Wu;J. Pharm. Sci.,2011

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1. An investigation of the metabolic activity, isozyme contribution, species differences and potential drug–drug interactions of PI-103, and the identification of efflux transporters for PI-103-O-glucuronide in HeLa1A9 cells;RSC Advances;2020

2. Potential metabolism determinants and drug–drug interactions of a natural flavanone bavachinin;RSC Advances;2020

3. Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1;PLOS ONE;2019-05-31

4. The Efflux Mechanism of Fraxetin-O-Glucuronides in UGT1A9-Transfected HeLa Cells: Identification of Multidrug Resistance-Associated Proteins 3 and 4 (MRP3/4) as the Important Contributors;Frontiers in Pharmacology;2019-05-07

5. An update on polyphenol disposition via coupled metabolic pathways;Expert Opinion on Drug Metabolism & Toxicology;2018-12-24

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