A rare adverse event of atorvastatin inducing leukocytoclastic vasculitis with ANCA‐negative (Anti‐Neutrophil cytoplasmic antibody) case report and literature review

Abstract

AbstractLeukocytoclastic vasculitis is an entity associated with drugs, infections, cryoglobulinemia, and connective tissue diseases but can also be idiopathic, systemic, or organ localized. Moreover, LCV associated with drugs is a rare disorder. When it is present usually has an elevation of anti‐neutrophil cytoplasmic antibody, most likely anti‐myeloperoxidase, which can be helpful to orient the diagnosis. We are presenting a 55‐year‐old female with a past medical history of diabetes mellitus (DM) and hyperlipidemia (HLD) who presented with a painful and pruritic rash localized in the abdomen and lower extremities that started 1 week after initiated atorvastatin for management of hyperlipidemia. This is the first case ever reported of leukocytoclastic vasculitis ANCA negative associated with atorvastatin, to our best knowledge.