In vitro and in vivo drug disposition of cilengitide in animals and human-Reference-Cited by-同舟云学术

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In vitro and in vivo drug disposition of cilengitide in animals and human

Published:2016-03-17 Issue:2 Volume:4 Page:e00217
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol Res Perspect

Author:

Dolgos Hugues¹,Freisleben Achim¹,Wimmer Elmar¹,Scheible Holger¹,Krätzer Friedrich¹,Yamagata Tetsuo¹,Gallemann Dieter¹,Fluck Markus¹

Affiliation:

1. Global Early Development/Quantitative Pharmacology and Drug Disposition (QPD); Merck Grafing Germany

Funder

Merck

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/prp2.217/fullpdf

Reference31 articles.

1. Integrin alpha v beta 3 antagonist cilengitide enhances efficacy of radiotherapy in endothelial cell and nonsmall-cell lung cancer models;Albert;Int J Radiat Oncol Biol Phys,2006

2. Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells;Aoudjit;Oncogene,2001

3. Metabolism and disposition of the αv-integrin β3/β5 receptor antabonist cilengitide, a cyclic polypeptide, in humans;Becker;J Clin Pharmacol,2015

4. Cilengitide (EMD 121974, NSC 707544) in asymptomatic metastatic castration resistant prostate cancer patients: A randomized phase II trial by the prostate cancer clinical trials consortium;Bradley;Invest New Drugs,2011

5. Src kinase activity is required for integrin alphaVbeta3-mediated activation of nuclear factor- kappa (2005);Courter;B. J Biol Chem.,2005

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