Utility of colonic manometry in children with Hirschsprung disease

Author:

Fu Yinan1,Gayer Christopher2,Gould Michelle1,Sicolo Anita R.1,Danialifar Tanaz F.1,Van Speybroeck Alexander3,Ambartsumyan Lusine4,Punati Jaya1

Affiliation:

1. Department of Pediatric Gastroenterology Children's Hospital Los Angeles Los Angeles California USA

2. Department of Pediatric Surgery Children's Hospital Los Angeles Los Angeles California USA

3. Department of General Pediatrics Children's Hospital Los Angeles Los Angeles California USA

4. Department of Pediatric Gastroenterology Seattle Children's Hospital Seattle Washington USA

Abstract

AbstractObjectives:Abnormal motility of the residual colon has been reported in post‐pull‐through Hirschsprung disease (PT‐HSCR) patients with persistent defecation problems. We reviewed the role of colonic manometry (CM) in the management of defecation disorders in these patients.Methods:We retrospectively reviewed the medical record of PT‐HSCR children who underwent CM for persistent symptoms of abnormal defecation. We reviewed their clinical course and its relation to CM findings.Results:Thirty PT‐HSCR patients underwent CM, of which five were diagnosed with transition zone pull‐through and were excluded. Of the remaining 25 patients, 16 had colonic dysmotility, 8 had normal CM, and one had colonic hypermotility. In patients with dysmotility, five responded to ongoing medical management, three required surgical intervention (ileostomy), three remained symptomatic with medical management but not yet received surgical intervention, and five were lost to follow‐up. In patients with normal CM, four responded to ongoing medical therapy, two required additional surgery (antegrade enema procedure), and two were lost to follow‐up. The patient with hypermotility improved with adding loperamide.Conclusions:Colonic dysmotility can occur in PT‐HSCR patients with persistent defecation problems. CM was helpful in delineating the degree of colonic neuromuscular dysfunction. CM results were used in conjunction with other clinical data to determine optimal management. Our findings support that medical management should first be optimized before consideration of colonic manometry and surgical interventions.

Publisher

Wiley

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Hirschsprung disease: common and uncommon variants;World Journal of Pediatric Surgery;2024-08

2. Colonic manometry: Still an important modality in pediatric Hirschsprung disease;Journal of Pediatric Gastroenterology and Nutrition;2024-04-29

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