Structural determinants in bacterial 2-keto-3-deoxy-D-gluconate dehydrogenase KduD for dual-coenzyme specificity

Author:

Takase Ryuichi1,Maruyama Yukie1,Oiki Sayoko1,Mikami Bunzo2,Murata Kousaku1,Hashimoto Wataru1

Affiliation:

1. Laboratory of Basic and Applied Molecular Biotechnology Graduate School of Agriculture, Kyoto University; Uji Kyoto Japan

2. Laboratory of Applied Structural Biology Graduate School of Agriculture, Kyoto University; Uji Kyoto Japan

Funder

Japan Society for the Promotion of Science

Program for Promotion of Basic Research Activities for Innovative Biosciences of Japan

Targeted Proteins Research Program by the Ministry of Education, Culture, Sports, Science, and Technology of Japan

Noda Institute for Scientific Research

Japan Society for the Promotion of Science for Young Scientists

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

Reference46 articles.

1. Medium- and short-chain dehydrogenase/reductase gene and protein families: the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes;Kavanagh;Cell Mol Life Sci,2008

2. Short-chain dehydrogenases/reductases (SDR): the 2002 update;Oppermann;Chem Biol Interact,2003

3. Chemical and biological evolution of nucleotide-binding protein;Rossmann;Nature,1974

4. Alginic acid metabolism in bacteria. II. The enzymatic reduction of 4-deoxy-l-erythro−5-hexoseulose uronic acid to 2-keto-3-deoxy-d-gluconic acid;Preiss;J Biol Chem,1962

5. Molecular identification of unsaturated uronate reductase prerequisite for alginate metabolism in Sphingomonas sp. A1;Takase;Biochim Biophys Acta,2010

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