Endolysosomal cholesterol export: More than just NPC1
Author:
Affiliation:
1. Departament de Biomedicina, Unitat de Biologia Cellular, Facultat de Medicina i Ciències de la Salut, Centre de Recerca Biomèdica CELLEX, Institut d'Investigacions Biomèdiques August Pi i Sunyer Universitat de Barcelona Barcelona Spain
Funder
Michael J. Fox Foundation for Parkinson's Research
Publisher
Wiley
Subject
General Biochemistry, Genetics and Molecular Biology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/bies.202200111
Reference110 articles.
1. NPC intracellular cholesterol transporter 1 (NPC1)-mediated cholesterol export from lysosomes
2. Glycosylation inhibition reduces cholesterol accumulation in NPC1 protein-deficient cells
3. Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD
4. Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4
5. Mannose 6-phosphate receptors, Niemann-Pick C2 protein, and lysosomal cholesterol accumulation
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