Affiliation:
1. Department of Cell Physiology and Metabolism Faculty of Medicine University of Geneva Geneva Switzerland
2. Translational Research Centre in Onco‐haematology Faculty of Medicine University of Geneva Geneva Switzerland
Abstract
AbstractThe accuracy of cell division requires precise regulation of the cellular machinery governing DNA/genome duplication, ensuring its equal distribution among the daughter cells. The control of the centrosome cycle is crucial for the formation of a bipolar spindle, ensuring error‐free segregation of the genome. The cell and centrosome cycles operate in close synchrony along similar principles. Both require a single duplication round in every cell cycle, and both are controlled by the activity of key protein kinases. Nevertheless, our comprehension of the precise cellular mechanisms and critical regulators synchronizing these two cycles remains poorly defined. Here, we present our hypothesis that the spatiotemporal regulation of a dynamic equilibrium of mitotic kinases activities forms a molecular clock that governs the synchronous progression of both the cell and the centrosome cycles.
Funder
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung