Affiliation:
1. Laboratory of Protein Metabolism Tokyo Metropolitan Institute of Medical Science Setagaya‐ku Tokyo Japan
2. Cell Biology Center Institute of Innovative Research Tokyo Institute of Technology Yokohama Japan
3. School of Life Science and Technology Tokyo Institute of Technology Yokohama Japan
Abstract
AbstractCells utilize diverse organelles to maintain homeostasis and to respond to extracellular stimuli. Recently, multifaceted aspects of organelle stress caused by various factors have been emerging. The endosome is an essential organelle, functioning as the central hub for membrane trafficking in cooperation with the ubiquitin system. However, knowledge regarding endosomal stress, which refers to organelle stress of the endosome, is currently limited. We recently revealed ubiquitin‐mediated endosomal stress of early endosomes (EEs) and its responsive signaling pathways. These findings shed light on the relevance of ubiquitin‐mediated endosomal stress to physiological and pathological processes. Here, we present a hypothesis that ubiquitin‐mediated endosomal stress may have significant roles in biological contexts and that ubiquitin‐specific protease 8 is a key regulator of ubiquitin clearance from EEs.
Funder
Takeda Science Foundation
Core Research for Evolutional Science and Technology
Japan Agency for Medical Research and Development
Japan Society for the Promotion of Science