Affiliation:
1. Key Laboratory of Laboratory Medicine Ministry of Education School of Laboratory Medicine and Life Sciences Wenzhou Medical University Wenzhou 325035 China
2. Institute for Regenerative Medicine Shanghai East Hospital School of Life Sciences and Technology Tongji University Shanghai 200092 China
Abstract
AbstractAging and regeneration are opposite cellular processes. Aging refers to progressive dysfunction in most cells and tissues, and regeneration refers to the replacement of damaged or dysfunctional cells or tissues with existing adult or somatic stem cells. Various studies have shown that aging is accompanied by decreased regenerative abilities, indicating a link between them. The performance of any cellular process needs to be supported by the energy that is majorly produced by mitochondria. Thus, mitochondria may be a link between aging and regeneration. It should be interesting to discuss how mitochondria behave during aging and regeneration. The changes of mitochondria in aging and regeneration discussed in this review can provide a timely and necessary study of the causal roles of mitochondrial homeostasis in longevity and health.
Funder
National Natural Science Foundation of China
Medical Science and Technology Project of Zhejiang Province